Assessing the genotoxicity of oral titanium dioxide nanoparticle administration in male rats using micronuclei and comet assay
نویسندگان
چکیده
منابع مشابه
Oral toxic exposure of titanium dioxide nanoparticles on serum biochemical changes in adult male Wistar rats
Objective(s): Titanium dioxide (TiO2) nanoparticles (NPs) are widely used in commercial food additives and cosmetics worldwide. Uptake of these nanoparticulate into humans by different routes and may exhibit potential side effects, lags behind the rapid development of nanotechnology. Thus, the present study designed to evaluate the toxic effect of mixed rutile and anatase TiO2 NPs on serum bioc...
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چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولMercury chloride genotoxicity in rats following oral exposure, evaluated by comet assay and micronucleus test.
Mercury is a toxic element which is easily absorbed after ingestion or inhalation and deposited mainly in the kidney. The aim of this study was to evaluate the effects of mercury chloride in rats. Female rats, aged 14 weeks, were receiving mercury chloride in oral doses of 0.068, 0.136, and 0.272 mg kg(-1) body weight (b.wt.) for five consecutive days. Three days after the last dose, the animal...
متن کاملEvaluation of epigenetic changes of liver tissue induced by oral administration of Titanium dioxide nanoparticles and possible protective role of Nigella Sativa oil, in adult male albino rats
Objective (s): Titanium dioxide nanoparticles (TiO2 NPs) have been recognized as biologically inert material and have been used in a multitude of applications. Nevertheless, the negative impact on the human health is not yet well understood. Aim of the work: The study attempted to evaluate the epigenetic changes of the genome, in the form of DNA methylation in liver tissue samples, resulting fr...
متن کاملGenotoxicity assessment using micronuclei assay in rheumatoid arthritis patients.
OBJECTIVES This study investigated whether: (i) rheumatoid arthritis (RA) patients have more micronuclei (MN) than healthy controls; (ii) methotrexate (MTX) treated RA patients have more MN than those not using MTX, and (iii) folic acid supplementation decreases the number of MN in MTX treated patients. METHODS MN assays were performed in oral mucosa sweeps of 50 consecutive MTX treated RA pa...
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ژورنال
عنوان ژورنال: Fayoum Journal of Agricultural Research and Development
سال: 2023
ISSN: ['1110-7790', '2805-2528']
DOI: https://doi.org/10.21608/fjard.2023.280936